A carbenapenem antibiotic
货号:ajcx25188
CAS:N/A
分子式:C16H21N3O4S2·XH2O
分子量：383.5
溶解度:DMSO: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tebipenem is a carbenapenem antibiotic.^1,2It is active against a panel of clinical isolates from a variety of bacterial species (MIC₅₀s = ≤0.0039-8 µg/ml), including methicillin-resistant strains ofS. aureusandS. epidermidisand penicillin-resistantS. pneumoniae.¹Tebipenem inhibits β-lactamase in a concentration-dependent manner.²It decreases the number of colony forming units (CFUs) in the lungs in a mouse model of penicillin-resistantS. pneumoniaeinfection when administered at doses ranging from 0.32 to 3.2 mg/kg.¹

1.Fujimoto, K., Takemoto, K., Hatano, K., et al.Novel carbapenem antibiotics for parenteral and oral applications: In vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animalsAntimicrob. Agents Chemother.57(2)697-707(2013) 2.Hazra, S., Xu, H., and Blanchard, J.S.Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosisBiochemistry53(22)3671-3678(2014)