规格: | 98% |
分子量: | 691.8 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
Background:
RS 09 is a peptide agonist of toll-like receptor 4 (TLR4).1It activates NF-κB in a concentration-dependent manner in a secreted alkaline phosphatase (SEAP) assay using TLR4-expressing HEK293 cells and induces NF-κB nuclear translocation in the same cells. It also induces cytokine secretion from RAW 264.7 cells. RS 09 (25 µg/animal) acts as an adjuvant in mice vaccinated with a KLH-conjugated X-15 antigen, with no antibodies produced in mice receiving RS 09 without the antigen.
1.Shanmugam, A., Rajoria, S., George, A.L., et al.Synthetic toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvantsPLoS One7(2)e30839(2012)