An internal standard for the quantification of β-muricholic acid
货号:ajcx24996
CAS:N/A
分子式:C24H36D4O5
分子量：412.6
溶解度:DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

β-Muricholic acid-d₄(β-MCA-d₄) is intended for use as an internal standard for the quantification of β-muricholic acid by GC- or LC-MS. β-MCA is a murine-specific primary bile acid.^1,2Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.³Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.⁴

1.Eyssen, H.J., Parmentier, G.G., and Mertens, J.A.Sulfate bile acids in germ-free and conventional miceEur. J. Biochem.66(3)507-514(1976) 2.WahlstrÖm, A., Sayin, S.I., Marschall, H.-I., et al.Intestinal crosstalk between bile acids and microbiota and its impact on host metabolismCell Metab.24(1)41-50(2016) 3.Fujino, Y., Nakayama, K., Yoshimura, K., et al.Suppression of hepatic HMG-CoA reductase activity by β-muricholic acid in mice fed a diet containing cholesterol and cholic acidJpn. J. Pharmacol.46(4)421-423(1988) 4.Wang, D.Q.-H., and Tazuma, S.Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J miceJ. Lipid. Res.43(11)1960-1968(2002)