您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Lovastatin-d9
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Lovastatin-d9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lovastatin-d9图片
包装:1mg
规格:98%
市场价:3333元
分子量:413.6

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22848
CAS:N/A
分子式:C24H27D9O5
分子量:413.6
溶解度:Chloroform: slightly soluble,Methanol: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Lovastatin-d9is intended for use as an internal standard for the quantification of lovastatin by GC- or LC-MS. Lovastatin is an HMG-CoA reductase inhibitor that was originally isolated fromA. terreus.1It is a prodrug of its more potent metabolite, lovastatin hydroxy acid . Both competitively inhibit HMG-CoA reductase with Kivalues of 1.4 and 0.6 nM for lovastatin and the open ring, hydroxy acid form, respectively.2Lovastatin (8 mg/kg per day) reduces plasma cholesterol in dogs by 29% over a three-week period. It also suppresses TNF-induced NF-κB activation (IC50= ~15 µM), which potentiates apoptosis in human myeloid leukemia cells.3Formulations containing lovastatin were the first HMG-CoA reductase inhibitors to be used in the treatment of hypercholesterolemia.


1.Endo, A.The discovery and development of HMG-CoA reductase inhibitorsJ. Lipid Res.33(11)1569-1582(1992) 2.Alberts, A.W., Chen, J., Kuron, G., et al.Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agentProc. Natl. Acad. Sci. USA77(7)3957-3961(1980) 3.Ahn, K.S., Sethi, G., and Aggarwal, B.B.Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathwayBiochem. Pharmacol.75(4)907-913(2008)