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JWH 018 N-pentanoic acid metabolite-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JWH 018 N-pentanoic acid metabolite-d5图片
规格:98%
分子量:376.5
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22716
CAS:N/A
分子式:C24H16D5NO3
分子量:376.5
溶解度:DMF: 30 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

JWH 018 N-pentanoic acid metabolite-d5contains five deuterium atoms at the 2, 4, 5, 6, and 7 positions. It is intended for use as an internal standard for the quantification of JWH 018 N-pentanoic acid metabolite by GC-or LC-mass spectrometry (MS). JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Kivalues for binding central cannabinoid (CB1) and CB2receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2ratio of 3.06.1JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. JWH 018 N-pentanoic acid metabolite is a minor urinary metabolite of JWH 018, characterized by carboxylation of the N-alkyl chain.2In urine samples, this metabolite is almost completely glucuronidated.2


1.Aung, M.M., Griffin, G., Huffman, J.W., et al.Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor bindingDrug Alcohol Depend.60(2)133-140(2000) 2.Sobolevsky, T., Prasolov, I., and Rodchenkov, G.Detection of JWH-018 metabolites in smoking mixture post-administration urineForensic Sci. Int.200(1-3)141-147(2010)