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Docosahexaenoyl Ethanolamide-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Docosahexaenoyl Ethanolamide-d4图片
规格:98%
分子量:375.6
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of docosahexaenoyl ethanolamide
货号:ajcx22340
CAS:946524-43-2
分子式:C24H33D4NO2
分子量:375.6
溶解度:DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 0.15 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Docosahexaenoyl ethanolamide-d4contains four deuterium atoms at the 1, 1', 2, and 2' positions. It is intended for use as an internal standard for the quantification of docosahexaenoyl ethanolamide by GC-or LC-mass spectrometry (MS). Docosahexaenoic Acid (DHA) is an essential fatty acid and the most abundant ω-3 fatty acid in neural tissues, especially in the retina and brain. Docosahexaenoyl ethanolamide (DHEA) is the ethanolamine amide of DHA that has been detected in both brain and retina at concentrations similar to those for arachidonoyl ethanolamide (AEA).1,2A 9.5 fold increase of DHEA was observed in brain lipid extracts from piglets fed a diet supplemented with DHA compared to a control diet without DHA.3DHEA binds to the rat brain CB1receptor with a Kivalue of 324 nM, which is approximately 10-fold higher than the Kivalue for AEA.4DHEA inhibits shaker-related voltage-gated potassium channels in brain slightly better than AEA, with an IC50value of 1.5 µM.5


1.Sugiura, T., Kondo, S., Sukagawa, A., et al.Transacylase-mediated and phosphodiesterase-mediated synthesis of N-arachidonoylethanolamine, an endogenous cannabinoid-receptor ligand, in rat brain microsomes. Comparison with synthesis from free arachidonic acid and ethanolamineEuropean Journal of Biochemistry24053-62(1996) 2.Bisogno, T., Delton-Vandenbroucke, I., Milone, A., et al.Biosynthesis and inactivation of N-Arachidonoylethanolamine (Ananadamide) and N-Docosahexaenoylethanolamine in bovine retinaArchives of Biochemistry and Biophysics370(2)300-307(1999) 3.Berger, A., Crozier, G., Bisogno, T., et al.Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in pigletsProceedings of the National Academy of Sciences of the United States of America98(11)6402-6406(2001) 4.Sheskin, T., Hanus, L., Slager, J., et al.Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptorJournal of Medicinal Chemistry40659-667(1997) 5.Poling, J.S., Rogawski, M.A., Salem, N., Jr., et al.Anadamide, an endogenous cannabinoid, inhibits shaker-related voltage-gated K+ channelsNeuropharmacology35(7)983-991(1996)