A glycoside form of 3-demethylcolchicine
货号:ajcx22128
CAS:477-29-2
分子式:C27H33NO11
分子量：547.6
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Colchicoside is a glycoside form of 3-demethylcolchicine that has been found inG. superba.¹Unlike cholchicine and 3-demethylcolchicine, colchicoside does not displace [³H]-colchicine from rat brain tubulinin vitrowhen used at a concentration of 25 μM.²Colchicoside (1 and 10 μM) increases levels of the cytochrome P450 (CYP) isoforms CYP2C9 and CYP2E1 in primary human hepatocytes.³

1.Capistrano, I.R., Vangestel, C., Vanpachtenbeke, H., et al.Coadministration of a Gloriosa superba extract improves the in vivo antitumoural activity of gemcitabine in a murine pancreatic tumour modePhytomedicine23(12)1434-1440(2016) 2.Sugio, K., Maruyama, M., Tsurufuji, S., et al.Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congenersLife Sci.40(1)35-39(1987) 3.DvorÁk, Z., UlrichovÁ, J., ModrianskÝ, M., et al.Effect of colchicine and its derivatives on the expression of selected isoforms of cytochrome P450 in primary cultures of human hepatocytesActa Univ. Palacki. Olomuc. Fac. Med.14347-50(2000)