A neuropeptide with diverse biological activities
货号:ajcx21790
CAS:N/A
分子式:C19H15D10NS
分子量：309.5
溶解度:DMF: 5 mg/ml,Ethanol: 2 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Benocyclidine-d₁₀(BCP-d₁₀) contains ten deuterium atoms at the 2, 2', 3, 3', 4, 4', 5, 5', 6, and 6' positions. It is intended for use as an internal standard for the quantification of BCP by GC-or LC-mass spectrometry. BCP is a derivative of phencyclidine with a benzothiophenyl group instead of a phenyl ring. It acts as a potent and selective dopamine reuptake inhibitor (IC₅₀= 8 nM) with negligible affinity for the NMDA receptor-linked phencyclidine receptor (K_0.5= 6 μM).^1,2BCP has been used to label the dopamine transporter in the mouse brain.³This product is intended for forensic and research applications.

1.Vignon, J., Pinet, V., Cerruti, C., et al.[3H]N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine ([3H]BTCP): A new phencyclidine analog selective for the dopamine uptake complexEuropean Journal of Pharmacology148(3)427-436(1988) 2.Chaudieu, I., Vignon, J., Chicheportiche, M., et al.Role of the aromatic group in the inhibition of phencyclidine binding and dopamine uptake by PCP analogsPharmacology, Biochemistry, and Behavior32(3)699-705(1989) 3.Maurice, T., Vignon, J., Kamenka, J.M., et al.In vivo labelling of the mouse dopamine uptake complex with the phencyclidine derivative [3H]BTCPNeuroscience Letters101(2)234-238(1989)