A neuropeptide with diverse biological activities
货号:ajcx21536
CAS:N/A
分子式:C20H28D4O5
分子量：356.5
溶解度:DMF: >100 mg/ml,DMSO: >100 mg/ml,Ethanol: >100 mg/ml,PBS (pH 7.2): >5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

8-isoProstaglandin E₂-d₄(8-isoPGE₂-d₄) contains four deuterium atoms at the hydroxyethyl 3, 3',4, and 4' positions. It is intended for use as an internal standard for the quantification of 8-isoPGE₂by GC-or LC-mass spectrometry. 8-isoPGE₂is one of several isoprostanes produced from arachidonic acid during lipid peroxidation.¹It is a potent renal vasoconstrictor in the rat.^1,28-isoPGE₂inhibits U-46619 or I-BOP-induced platelet aggregation with IC₅₀values of 0.5 and 5 µM, respectively.³When infused into the renal artery of the rat at a concentration of 4 mg/kg/min, 8-isoPGE₂decreases the GFR and renal plasma flow by 80% without affecting blood pressure.¹

1.Morrow, J.D., Minton, T.A., Mukundan, C.R., et al.Free radical-induced generation of isoprostanes in vivo. Evidence for the formation of D-ring and E-ring isoprostanesThe Journal of Biological Chemisty2694317-4326(1994) 2.Hoffman, S.W., Moore, S., and Ellis, E.F.Isoprostanes: Free radical-generated prostaglandins with constrictor effects on cerebral arteriolesStroke28844-884(1997) 3.Longmire, A.W., Roberts, L.J., and Morrow, J.D.Actions of the E2-isoprostane, 8-iso-PGE2, on the platelet thromboxane/endoperoxide receptor in humans and rats: Additional evidence for the existence of a unique isoprostane receptorProstaglandins48247-256(1994)