| 规格: | 98% |
| 分子量: | 586.1 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
Background:
8-Bromoadenosine 5'-triphosphate (8-Br-ATP) is an analog of ATP and an agonist of the purinergic P2X receptor.1It induces contraction of isolated guinea pig bladder strips with a potency that is 0.19-fold that of ATP. 8-Br-ATP has been used in the determiniation of the nucleotide substrate specificity of yeast poly(A) polymerase.2It is cytotoxic to multiple myeloma cells (IC50= 23.1 μM).3
1.Howson, W., Taylor, E.M., Parsons, M.E., et al.Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder)Eur. J. Med. Chem.23(5)433-439(1988) 2.Chen, L.S., and Sheppard, T.L.Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogsJ. Biol. Chem.279(39)40405-40411(2004) 3.Wang, L., and MacDonald, R.C.Cationic phospholiposomes: Efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cellsJ. Liposome Res.21(4)306-314(2011)
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