您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > LH1307
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
LH1307
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LH1307图片
规格:98%
分子量:915.1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A PD-1/PD-L1 interaction inhibitor
货号:ajcx20302
CAS:2375720-38-8
分子式:C54H58N8O6
分子量:915.1
溶解度:DMF: 25 mg/ml,DMSO: 25 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml,Ethanol: 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

LH1307 is an inhibitor of the interaction between programmed cell death 1 (PD-1) and its ligand PD-L1 that has an IC50 value of 3 nM in a homologous time-resolved fluorescence (HTRF) assay.1 It increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays).


|1. Basu, S., Yang, J., Xu, B., et al. Design, synthesis, evaluation, and structural studies of C2-symmetric small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 protein-protein interaction. J. Med. Chem. 62(15), 7250-7263 (2019).