Sermorelin is a 29-residue N-terminal analog of growth hormone-releasing hormone (GHRH) that retains the ability to stimulate growth hormone (GH) release.
货号:ajcx18976
CAS:N/A
分子式:C149H246N44O42S•XCF3COOH
分子量：3357.9
溶解度:Formic Acid: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Sermorelin is a 29-residue N-terminal analog of growth hormone-releasing hormone (GHRH) that retains the ability to stimulate growth hormone (GH) release. Sermorelin (1 μg/kg, i.v.) increases serum GH levels in rats by approximately 17% compared with saline control after 15 minutes. It also increases GH release in pigs when administered at a dose of 250 ng/kg. Sermorelin (1 μM) increases proliferation of NCI-H727 human bronchial carcinoid cells by 30% and increases vascular endothelial growth factor (VEGF) secretion. It increases phosphorylation of focal adhesion kinase (FAK) and expression of VEGF in A549 lung cancer cells when used at a concentration of 0.1 μM. Formulations containing sermorelin have been used to diagnose and treat growth hormone deficiency.