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PK7242(maleate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PK7242(maleate)图片
规格:98%
分子量:414.4
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
The protein p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis.
货号:ajcx18846
CAS:N/A
分子式:C17H19FN4•C4H4O4
分子量:414.4
溶解度:DMF: 30 mg/ml,DMSO: 16 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): 2 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

The protein p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis. Its role as a tumor suppressor is evident by the observation that approximately 50% of human tumors have mutated or non-functional p53. PK7242 is an inducer of reactivation of mutant p53 in cancer cells. In cancer cells carrying the Y220C mutant, PK7242 binds to the p53-Y220C core domain and induces growth inhibition, cell-cycle arrest, and apoptosis.