PBD-150 是人谷氨酰胺酰基环化酶 (hQC) Y115E-Y117E 变体的抑制剂，其 Ki 值为490 nM。
货号:ajcx16598
CAS:790663-33-1
分子式:C15H20N4O2S
分子量：320.41
溶解度:DMSO: 125 mg/mL (390.13 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PBD-150 is a human glutaminyl cyclase (hQC) Y115E-Y117E variant inhibitor, with a Ki value of 490 nM[1][2].

[1]. Buchholz M, et al. The first potent inhibitors for human glutaminyl cyclase: synthesis and structure-activity relationship. J Med Chem. 2006 Jan 26;49(2):664-77. [2]. DiPisa F, et al. The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):986-92. [3]. Huang KF, et al. Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding. J Biol Chem. 2011 Apr 8;286(14):12439-49.