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EN40
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EN40图片
规格:98%
分子量:217.26
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
EN40 是一种有效的选择性乙醛脱氢酶 3A1 (ALDH3A1) 抑制剂,一种共价配体,IC50 值为 2 uM。
货号:ajcx15602
CAS:2094547-67-6
分子式:C13H15NO2
分子量:217.26
溶解度:DMSO: 5 mg/mL (23.01 mM); Ethanol: 2 mg/mL (9.21 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM[1]

EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival[1]. Cell Viability Assay[1] Cell Line: A549 cells

EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice[1]. Animal Model: SCID mice with A549 cells[1]

[1]. Counihan JL,et al.Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.ACS Chem Biol. 2018 Aug 17;13(8):1970-1977