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BMS-1001 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS-1001 hydrochloride图片
规格:98%
分子量:631.11
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
BMS-1001 hydrochloride 是具有口服活性的、人 PD-L1/PD-1 免疫检查点的抑制剂。BMS-1001 hydrochloride 具有细胞毒性低的特点。
货号:ajcx15266
CAS:2113650-04-5
分子式:C35H35ClN2O7
分子量:631.11
溶解度:DMSO: 12.5 mg/mL (19.81 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

BMS-1001 hydrochloride is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 hydrochloride exhibits low-toxicity in cells[1].

BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 presents low toxicity towards tested cell lines and block the interaction of soluble PD-L1 with the cell surface-expressed PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes[1].


[1]. Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.