您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Ilorasertib hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Ilorasertib hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ilorasertib hydrochloride图片
规格:98%
分子量:525
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
Ilorasertib hydrochloride (ABT-348 hydrochloride) 是一种有效、ATP 竞争性的多靶点激酶抑制剂,可抑制 Aurora C,Aurora B 和 Aurora A 的活性,IC50 值分别为 1 nM,7 nM 和 120 nM。Ilorasertib hydrochloride (ABT-348 hydrochloride) 同时抑制 RET,PDGFRβ 和 Flt1 的活性,IC50 值分别为 7 nM,3 nM 和 32 nM。
货号:ajcx14908
CAS:1847485-91-9
分子式:C25H22ClFN6O2S
分子量:525
溶解度:DMSO: 41.67 mg/mL (79.37 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Ilorasertib hydrochloride (ABT-348 hydrochloride) is a potent and ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A with IC50s of 1 nM, 7 nM, 120 nM, respectively. Ilorasertib hydrochloride (ABT-348 hydrochloride) also suppresses RET tyrosine kinase, PDGFRβ and Flt1 with IC50s of 7 nM, 3 nM and 32 nM, respectively[1].


[1]. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.