PROTAC ERαDegrader-1

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

规格:	98%
分子量:	1120.29

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

PROTACERαDegrader-1包含泛素E3连接酶结合基团，linker和靶蛋白结合基团。PROTACERαDegrader-1的详细信息请参考专利文献WO2017201449A1中的化合物P1。PROTACERαDegrader-1降低雌激素受体-α(ERα)水平。
货号:ajcx13404
CAS:2417369-94-7
分子式:C66H69N7O10
分子量：1120.29
溶解度:DMSO: 200 mg/mL (178.53 mM); H2O:< 0.1 mg/mL (insoluble)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PROTAC ERα Degrader-1 comprises an ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Degrader-1 extracts from patent WO2017201449A1, compound P1. PROTAC ERα Degrader-1 is an estrogen receptor-alpha (ERα) degrader.

Treatment of the HER2 expressing cells with the PROTAC ERα Degrader-1 (without Ab; compound P1) results in a decreased estrogen receptor-alpha (ERα) levels[1].

[1]. Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.

Protocol:

Kinase experiment:

Synthesis of a PROTAC: i. Attachment of a Linker (L2) to an E3 Ligase Binding Group (E3LB). ii. Attachment of a protein binding moiety (PB) to an E3LB via a Linker (L2)[1].

参考文献:

[1]. Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.