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ERK1/2 inhibitor 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ERK1/2 inhibitor 1图片
规格:98%
分子量:550.05
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
ERK1/2 inhibitor 1 是一种有效的,口服生物可利用的 ERK1/2 抑制剂,在 1 nM 时抑制 ERK1 达60%,抑制 ERK2 的 IC50 为 3.0 nM。
货号:ajcx39720
CAS:2095719-90-5
分子式:C29H32ClN5O4
分子量:550.05
溶解度:DMSO : 250 mg/mL (454.50 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively[1].

ERK1/2 inhibitor 1 (Compound 27) shows excellent antiproliferative potency with IC50s of 4.9 and 7.5 nM in A375 and Colo205 cells, respectively[1].

[1]. Heightman TD, et al. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J Med Chem. 2018 Jun 14;61(11):4978-4992.

Protocol:

ERK2

3.0nM(IC50)

ERK1