规格: | 98% |
分子量: | 309.36 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
Background:
Amino-PEG5-C2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG5-C2-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Gregory L. Verdine, et al. Stabilized polypeptide insulin receptor modulators. WO2014201370A1.
Protocol:
Non-cleavable
| PEGs
|