Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) 是一种嘌呤核糖核苷单磷酸，在核苷酸循环代谢 (nucleotide cycle metabolite) 中起作用。Adenylosuccinic acid tetraammonium 可以通过腺苷琥珀酸裂解酶转化成富马酸。Adenylosuccinic acid tetraammonium 有潜力用于杜氏肌营养不良症 (DMD) 的研究。
货号:ajcx38550
CAS:N/A
分子式:C14H30N9O11P
分子量：531.42
溶解度:H2O : 200 mg/mL (376.35 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Adenylosuccinic acid tetraammonium (Adenylosuccinate; Aspartyl adenylate) is a purine ribonucleoside monophosphate and plays a role in nucleotide cycle metabolite. Adenylosuccinic acid tetraammonium can be converted into fumaric acid through adenylosuccinate lyase. Adenylosuccinic acid tetraammonium has the potential for the study of duchenne muscular dystrophy(DMD)[1].

Adenylosuccinic acid tetraammonium (oral administration; 3-3000 µg/mL; 6 weeks) significantly improves the features of murine DMD, it decreases the number of centronucleated fibres, lipid accumulation, connective tissue infiltration and Ca2+ content of mdx tibialis anterior[1].

[1]. Timpani CA, et al. Adenylosuccinic acid tetraammonium therapy ameliorates murine Duchenne Muscular Dystrophy.Sci Rep. 2020 Jan 24;10(1):1125.