(Rac)-MGV354 是 MGV354 的外消旋体，MGV354 是一种可溶性鸟苷酸环化酶 (sGC) 活化剂，在 CHO 和 GTM-3E 细胞中 EC50 分别为<0.5 nM 和 5 nM。
货号:ajcx37718
CAS:1852495-86-3
分子式:C35H37N5O3
分子量：575.7
溶解度:DMSO : 100 mg/mL (173.70 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

(Rac)-MGV354 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of<0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively[1].

[1]. Ehara T, et al. The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma. J Med Chem. 2018 Mar 22;61(6):2552-2570.