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MM 419447
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MM 419447图片
规格:98%
分子量:1363.56
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
MM 419447,一种利那洛肽代谢物,是一种鸟苷酸环化酶 C (guanylate cyclase-C) 激动剂。MM 419447 可被用作研究便秘型肠易激综合征 (IBS-C)。
货号:ajcx35398
CAS:1092457-78-7
分子式:C50H70N14O19S6
分子量:1363.56
溶解度:DMSO : 100 mg/mL (73.34 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C)[1].

MM 419447 exhibits high-affinity binding to T84 cells, resulting in a significant, concentration-dependent accumulation of intracellular cyclic guanosine-39,59-monophosphate (cGMP)[1].

MM 419447 (10 mg/kg; p.o.) treatment shows the Cmax, AUC0-6 and t1/2 values of 27 ng/mL, ≤ 29.7 ng h/mL and 0.33 hours, respectively[1]

[1]. Busby RW, et al. Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation. J Pharmacol Exp Ther. 2013;344(1):196-206.