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LY3154207
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY3154207图片
规格:98%
分子量:450.4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
LY3154207 是一种有效的、亚型选择性的、口服的人多巴胺 D1 受体 (human dopamine D1 receptor) 正向变构调节剂 (PAM),具有最小的变构激动剂活性 (EC50=3 nM)。
货号:ajcx34926
CAS:1638667-79-4
分子式:C24H29Cl2NO3
分子量:450.4
溶解度:DMSO : 110 mg/mL (244.23 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

LY3154207 is a potent, subtype selective, and orally available human dopamine D1 receptorpositive allosteric modulator (PAM) with minimal allosteric agonist activity (EC50=3 nM)[1].

In HEK293 cells transiently expressing human, dog, rhesus monkey, and mouse D1 receptors, the EC50s of LY3154207 are 2.3 nM, 2.0 nM, 2.5 nM, and 62.1 nM, respectively[1].

[1]. Hao J, Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor. J Med Chem. 2019 Oct 10;62(19):8711-8732.