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Indican
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indican图片
包装:50mg
规格:98%
市场价:346元
分子量:295.29

产品介绍
Indican (Indoxyl-β-D-glucoside) 是吲哚酚的一种糖苷,染料靛蓝和靛玉红的前体。Indican 的主要代谢物是硫酸吲哚酚 (IS)。IS 是一种尿毒症毒素,是有机阴离子转运蛋白1 (OAT 1)、OAT 3 和多药耐药相关蛋白4 (MRP 4) 的底物/抑制剂。
货号:ajcx32980
CAS:487-60-5
分子式:C14H17NO6
分子量:295.29
溶解度:DMSO : 100 mg/mL (338.65 mM)|Methanol : 83.33 mg/mL (282.20 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Indican (Indoxyl-β-D-glucoside), a glycoside of indoxyl, is a precursor of the dyesindigo and indirubin. Indican has a major metabolite, indoxyl sulfate (IS). IS, an uremic toxin, is a substrate/inhibitor of organic anion transporter (OAT) 1, OAT 3 and multidrug resistance-associated protein (MRP) 4[1][2].


Indican ((Indoxyl-β-D-glucoside; oral; 20, 40 mg/kg; single dose) increases the systemic exposure and MRT of MTX through inhibition on multiple anion transporters including OAT 1, OAT 3 and MRP 4 by the major metabolite IS[1].

[1]. Shiuan-Pey Lin, et al. Transporter-mediated interaction of indican and methotrexate in rats. J Food Drug Anal. 2018 Apr;26(2S):S133-S140.
[2]. Yu-Chi Hou, et al. Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. Toxicon. 2008 Sep 1;52(3):440-4.