Tos-O-C4-NH-Boc是一种PROTAClinker，属于alkylether类。Boc-NH-C6-amido-C4-acid可用于合成PROTAC分子，例如BSJ-03-204。
货号:ajcx32208
CAS:180851-50-7
分子式:C16H25NO5S
分子量：343.44
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 [1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.