| 规格: | 98% |
| 分子量: | 306.35 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
Background:
Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. [2]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.
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