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SJF 1528
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SJF 1528图片
包装:5mg
规格:98%
市场价:4970元
分子量:1030.61

产品介绍
C55H57ClFN7O8S
货号:ajcx28168
CAS:2230821-38-0
分子式:C55H57ClFN7O8S
分子量:1030.61
溶解度:DMSO|103.06|100|
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib? joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).