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ELA-11(human)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装:1mg
规格:98%
市场价:2564元
分子量:1283.57

产品介绍
ELA-11 (human) 是一种肽,是人 apelin 受体的完全激动剂,pKi 为 7.85。
货号:ajcx27776
CAS:1784687-32-6
分子式:C58H90N16O13S2
分子量:1283.57
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

High affinity apelin receptor agonist (Ki = 14 nM). Bioactive fragment of ELA-32 . Inhibits forskolin-induced cAMP production and stimulates β-arrestin recruitment in vitro.


Yang et al (2017) Elabela/Toddler is an endogenous agonist of the apelin APJ receptor in the adult cardiovascular system, and exogenous administration of the peptide compensates for the downregulation of its expression in pulmonary arterial hypertension. Circulation 135 1160 PMID:28137936 |Murza et al (2016) Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions. J.Med.Chem. 59 2962 PMID:26986036