CRT 0105950 是一种有效的 LIMK 抑制剂，对 LIMK1 和 LIMK2 的 IC50 分别为 0.3 nM 和 1 nM。 CRT 0105950 可用于癌症研究。
货号:ajcx27498
CAS:1661845-86-8
分子式:C21H16ClN3OS
分子量：393.89
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent LIMK1/2 inhibitor (IC50 values are 0.3 and 1 nM at LIMK 1 and 2, respectively). Disrupts microtubule organization, inhibits cofilin phosphorylation and increases α-tubulin acetylation in vitro.

Charles et al (2015) Discovery, development, and SAR of aminothiazoles as LIMK inhibitors with cellular anti-invasive properties. J.Med.Chem. 58 8309 PMID:26356364 |Mardilovich et al (2015) LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget. 6 38469 PMID:26540348