| 规格: | 98% |
| 分子量: | 399.79 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
Background:
FFA2 inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.
Park et al (2016) Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 771 1 PMID:26683635 |Sergeev et al (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 291 303 PMID:26518871
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