| 规格: | 98% |
| 分子量: | 280.4 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
Background:
N-desmethyl Trimipramine is an active metabolite of the tricyclic antidepressant trimipramine .1It inhibits the norepinephrine transporter (NET), serotonin (5-HT) transporter (SERT), and dopamine transporter (DAT; IC50s = 2.92, 6.22, and 29.5 µM, respectively) as well as organic cation transporter 1 (OCT1) and OCT2 (IC50s = 3.19 and 10.4 µM, respectively) in HEK293 cells expressing the human transporters.
1.Haenisch, B., Hiemke, C., and BÖnisch, H.Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transportersPsychopharmacology (Berl)217(2)289-295(2011)
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