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Hepcidin-25(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hepcidin-25(trifluoroacetate salt)图片
包装:100ug
规格:98%
市场价:2758元
分子量:2789.4

产品介绍
A peptide hormone
货号:ajcx26030
CAS:N/A
分子式:C113H170N34O31S9 • XCF3COOH
分子量:2789.4
溶解度:Water: 1mg/mL
纯度:98%
存储:Store at -20°C
库存:现货

Background:


Hepcidin-25 is a peptide hormone that regulates iron homeostasis and has antibacterial activity.1It is predominantly synthesized by hepatocytes and secreted into the circulation. Hepcidin-25 binds to ferroportin, a membrane-bound iron exporter expressed by macrophages, enterocytes, and hepatocytes, inducing ferroportin internalization and degradation, which increases intracellular iron levels and decreases dietary iron absorption and plasma iron levels. It is bactericidal against multidrug-resistant clinical isolates of Gram-negative and Gram-positive bacteria, includingP. aeruginosa,E. coli,K. pneumoniae,S. aureus,S. epidermidis, andE. faecium, when used at concentrations ranging from 6.25 to 50 µg/ml.2Serum hepcidin-25 levels are increased in patients with chronic kidney disease (CKD).3


1.Kroot, J.J.C., Tjalsma, H., Fleming, R.E., et al.Hepcidin in human iron disorders: Diagnostic implicationsClin. Chem.57(12)1650-1669(2011) 2.Maisetta, G., Petruzzelli, R., Brancatisano, F.L., et al.Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: Effect of copper and acidic pHPeptides31(11)1995-2002(2010) 3.Tsuchiya, K., and Nitta, K.Hepcidin is a potential regulator of iron status in chronic kidney diseaseTher. Apher. Dial.17(1)1-8(2013)