An internal standard for the quantification of 2’-deoxyuridine
货号:ajcx25978
CAS:40632-23-3
分子式:C9H10D2N2O5
分子量：230.2
溶解度:DMF: 16 mg/mL,DMSO: 10mg/mL,Ethanol: slightly soluble,PBS (pH 7.2): 5mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

2’-Deoxyuridine-d₂is intended for use as an internal standard for the quantification of 2’-deoxyuridine by GC- or LC-MS. 2’-Deoxyuridine is a pyrimidine nucleoside composed of the pyrimidine base uracil attached to the sugar deoxyribose.¹It has been used as a precursor in the synthesis of antiviral deoxyuridine derivatives, including idoxuridine .^2,3Formulations containing 2’-deoxyuridine have been used in the deoxyuridine suppression test to identify vitamin B12 and/or folate deficiency and in the diagnosis of megaloblastic anemias.

1.MartÍ, R., LÓpez, L.C., and Hirano, M.Assessment of thymidine phosphorylase function: Measurement of plasma thymidine (and deoxyuridine) and thymidine phosphorylase activityMethods Mol. Biol.837121-133(2012) 2.Prusoff, W.H.Synthesis and biological activities of iododeoxyuridine, an analog of thymidineBiochim. Biophys. Acta.32(1)295-296(1959) 3.Bergstrom, D.E., and Ogawa, M.K.C-5 substituted pyrimidine nucleosides. 2. Synthesis via olefin coupling to organopalladium intermediates derived from uridine to 2’-deoxyuridineJ. Am. Chem. Soc.100(26)8106-8112(1978)