An active metabolite of ropinirole
货号:ajcx25322
CAS:106916-16-9
分子式:C13H18N2O
分子量：218.3
溶解度:DMF: 25 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-Despropyl ropinirole is an active metabolite of the dopamine D₂receptor agonist ropinirole .¹It increases extracellular acidification rates in CHO cells expressing human dopamine D₂, D₃, and D₄receptors (EC₅₀s = 0.63, 0.063, and 1.23 µM, respectively). N-Despropyl ropinirole is also a potential impurity found in commercial preparations of ropinirole.²

1.Coldwell, M.C., Boyfield, I., Brown, T., et al.Comparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cellsBr. J. Pharmacol.127(7)1696-1702(1999) 2.Coufal, P., Stulik, K., Claessens, H.A., et al.Separation and quantification of ropinirole and some impurities using capillary liquid chromatographyJ. Chromatogr. B Biomed. Sci. Appl.732(2)437-444(1999)