规格: | 98% |
分子量: | 379.5 |
包装 | 价格(元) |
500ug | 电议 |
1mg | 电议 |
Background:
Thromboxane B2-d9(TXB2-d9) is intended for use as an internal standard for the quantification of TXB2by GC- or LC-MS. TXB2is a stable, biologically inert metabolite formed from the non-enzymatic hydrolysis of TXA2, which has a half-life of about 30 seconds.1Urinary analysis of TXB2accurately reflects intrarenal TXA2synthesis, while measurement of 11-dehydro and 2,3-dinor thromboxane metabolites gives the best estimate of systemic TXA2secretion.2,3,4
1.Needleman, P., Moncada, S., Bunting, S., et al.Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxidesNature261(5561)558-560(1976) 2.Patrono, C., Ciabattoni, G., Patrignani, P., et al.Evidence for a renal origin of urinary thromboxane B2 in health and diseaseAdv. Prostaglandin Thromboxane Leukot. Res.11493-498(1983) 3.Lawson, J.A., Patrono, C., Ciabattoni, G., et al.Long-lived enzymatic metabolites of thromboxane B2 in the human circulationAnal. Biochem.155(1)198-205(1986) 4.Patrono, C., Ciabattoni, G., Pugliese, F., et al.Estimated rate of thromboxane secretion into the circulation of normal humansJ. Clin. Invest.77(2)590-594(1986)