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TG11-77(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TG11-77(hydrochloride)图片
规格:98%
分子量:436.9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx23588
CAS:2550393-38-7
分子式:C23H24N6O.HCl
分子量:436.9
溶解度:DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

TG11-77 is a brain-permeable antagonist of the prostaglandin E2(PGE2) receptor subtype EP2(KB= 9.7 nM).1It is selective for EP2over DP1, EP4, and IP receptors (KBs = 7,320, 5,300, and >10,000 nM, respectively). TG11-77 (0.3 and 1 μM) inhibits the expression of genes encoding COX-2, IL-1β, and IL-6 induced by LPS and the EP2receptor agonist ONO-AE1-259-01 in mouse BV-2 microglia expressing human EP2receptors.


1.Amaradhi, R., Banik, A., Mohammed, S., et al.Potent, selective, water soluble, brain-permeable EP2 receptor antagonist for use in central nervous system disease modelsJ. Med. Chem.63(3)1032-1050(2020)