An internal standard for the quantification of PGF1α
货号:ajcx23346
CAS:1542166-81-3
分子式:C20H27D9O5
分子量：365.6
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Prostaglandin F_1α-d₉(PGF_1α.-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of PGF_1αby GC-or LC-mass spectrometry. PGF_1αis the putative metabolite of dihomo-γ-linolenic acid (DGLA)viathe cyclooxygenase (COX) pathway. Both PGF_1αand PGF_2αhave been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10-11 M.¹PGF_1αbinds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF_2α.²It is only half as active as PGF_2αin inducing human respiratory smooth muscle contractionsin vitro.³

1.Moore, A., and Waring, C.P.Electrophysiological and endocrinological evidence that F-series prostaglandins function as priming pheromones in mature male Atlantic salmon (Salmo salar) PARRJ. Exp. Biol.199(Pt 10)2307-2316(1996) 2.Balapure, A.K., Rexroad, C.E., Jr., Kawada, K., et al.Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptorBiochem. Pharmacol.38(14)2375-2381(1989) 3.Karim, S.M.M., Adaikan, P.G., and Kottegoda, S.R.Prostaglandins and human respiratory tract smooth muscle: Structure activity relationshipAdvances in Prostaglandin and Thromboxane Research7969-980(1980)