您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Prostaglandin E2-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Prostaglandin E2-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Prostaglandin E2-d4图片
规格:98%
分子量:356.5
包装与价格:
包装价格(元)
50ug电议
100ug电议
500ug电议

产品介绍
An internal standard for the quantification of prostaglandin E2
货号:ajcx23340
CAS:34210-10-1
分子式:C20H28D4O5
分子量:356.5
溶解度:DMF: >100 mg/ml (from PGE2),DMSO: >100 mg/ml (from PGE2),Ethanol: >100 mg/ml (from PGE2),PBS pH 7.2: >5 mg/ml (from PGE2)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Prostaglandin E2-d4(PGE2-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGE2by GC-or LC-mass spectrometry. PGE2is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.1,2,3,4The effects of PGE2are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.5The affinity constants (Kd) of PGE2for these receptors range from 1-10 nM depending on the receptor subtype and tissue.


1.Willis, A.L., and Cornelsen, M.Repeated injection of prostaglandin E2 in rat paws induces chronic swelling and a marked decrease in pain thresholdProstaglandins3(3)353-357(1973) 2.Jackson, G.M., Sharp, H.T., and Varner, M.W.Cervical ripening before induction of labor: A randomized trial of prostaglandin E2 gel versus low-dose oxytocinAm. J. Obstet. Gynecol.171(4)1092-1096(1994) 3.Robert, A., Schultz, J.R., Nezamis, J.E., et al.Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administrationGastroenterology70(3)359-370(1976) 4.Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al.Prostaglandin E2 down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell linesBiochemistry34(16)5604-5609(1995) 5.Coleman, R.A., Smith, W.L., and Narumiya, S.International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypesPharmacol. Rev.46(2)205-229(1994)