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N-desmethyl Rosuvastatin(sodium salt hydrate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-desmethyl Rosuvastatin(sodium salt hydrate)图片
规格:98%
分子量:529.5
包装与价格：
包装价格(元)
500ug电议
1mg电议

产品介绍
An active metabolite of rosuvastatin
货号:ajcx23076
CAS:N/A
分子式:C21H24FN3O6S.2Na [H2O]
分子量：529.5
溶解度:DMSO: Slightly, heated,Methanol: slightly soluble,Water: slightly soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

N-desmethyl Rosuvastatin is an active metabolite of the HMG-CoA reductase inhibitor rosuvastatin .1,2N-desmethyl Rosuvastatin is formed when rosuvastatin undergoes demethylation, primarily by the cytochrome P450 (CYP) isoform CYP2C9 and to a lesser extent by CYP2C19 and CYP3A4.1


1.Macwan, J.S., Ionita, I.A., and Akhlaghi, F.A simple assay for the simultaneous determination of rosuvastatin acid, rosuvastatin-5S-lactone, and N-desmethyl rosuvastatin in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS)Anal. Bioanal. Chem.402(3)1217-1227(2012) 2.Bai, X., Wang, X.P., He, G.D., et al.Simultaneous determination of rosuvastatin, rosuvastatin-5 S-lactone, and N-desmethyl rosuvastatin in human plasma by UPLC-MS/MS and its application to clinical studyDrug Res. (Stuttg.)68(6)328-334(2018)