An IL-4 inhibitor
货号:ajcx22648
CAS:1332184-63-0
分子式:C18H12FN3O2
分子量：321.3
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml,Ethanol: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

IL-4 inhibitor is an inhibitor of IL-4.¹It binds to IL-4 with a K_dvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC₅₀= 1.81 μM). It is selective for IL-4 over IL-13 (EC₅₀= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC₅₀= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.

1.Quinnell, S.P., Leifer, B.S., Nestor, S.T., et al.A small-molecule inhibitor to the cytokine interleukin-4ACS Chem. Biol.15(10)2649-2654(2020)