A neuropeptide with diverse biological activities
货号:ajcx22630
CAS:N/A
分子式:C8H4D4N4.HCl
分子量：200.7
溶解度:DMSO: soluble,Methanol:Water (1:1): soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Hydralazine-d₄is intended for use as an internal standard for the quantification of hydralazine by GC- or LC-MS. Hydralazine is an orally bioavailable vasodilator and antihypertensive agent.¹It decreases DNA methylation in Jurkat cells at a concentration of 10 μM and inhibits extracellular and intracellular production of reactive oxygen species (ROS) in rat macrophages activated by phorbol 12-myristate 13-acetate at a concentration of 100 μM.^2,3Hydralazine (100 μM) also decreases nitric oxide production and expression of inducible nitric oxide synthase (iNOS) in rat macrophages activated by LPS and interferon-γ (IFN-γ).³It reduces contraction of rat aortic arterial strips induced by potassium and norepinephrine .⁴Hydralazine (2.6 mg/kg) lowers mean arterial blood pressure (MAP) by 41.76% in conscious rats.⁵Formulations containing hydralazine have been used in the treatment of high blood pressure and heart failure.

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