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EOS-d9(d18:1-d9/32:0/18:2)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
EOS-d9(d18:1-d9/32:0/18:2)图片
包装:1mg
规格:98%
市场价:8149元
分子量:1049.8

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx22424
CAS:N/A
分子式:C68H120D9NO5
分子量:1049.8
溶解度:Chloroform: soluble,DMF: soluble,Methanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

EOS-d9(d18:1-d9/32:0/18:2) is intended for use as an internal standard for the quantification of EOS by GC- or LC-MS. EOS is a ceramide found in the outer layer of the epidermis in mammals.1It is comprised of an ω-hydroxy very long-chain fatty acid (C28-36) esterified to the essential fatty acid linoleic acid and glucosylated to sphingosine. The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte. [Matreya, LLC. Catalog No. 2208]


1.Zheng, Y., Yun, H., Boeglin, W.E., et al.Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: A proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelopeJ. Biol. Chem.286(27)24046-24056(2011)