秋水仙碱-d6 是氘标记的秋水仙碱。秋水仙碱是一种微管蛋白抑制剂和微管破坏剂。秋水仙碱抑制微管聚合，IC50 为 3 nM。秋水仙碱也是 α3 甘氨酸受体 (GlyRs) 的竞争性拮抗剂。
货号:ajcx22126
CAS:1217651-73-4
分子式:C22H19D6NO6
分子量：405.5
溶解度:Chloroform: Slightly Soluble,Methanol: Slightly Soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Colchicine-d₆is intended for use as an internal standard for the quantification of colchicine by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC₅₀= 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.¹It inhibits growth of MCF-7 human breast carcinoma cells with an IC₅₀value of 13 nM.¹Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.^2,3

1.Martino, G.D., Regina, G.L., Coluccia, A., et al.Arylthioindoles, potent inhibitors of tubulin polymerizationJ. Med. Chem.47(25)6120-6123(2004) 2.McCarty, D.J.Urate crystals, inflammation, and colchicineArthritis Rheum.58(2)S20-S24(2008) 3.Chia, E.W., Grainger, R., and Harper, J.L.Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicineBr. J. Pharmacol.153(6)1288-1295(2008)