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Asperglaucide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Asperglaucide图片
规格:98%
分子量:444.5
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An amide with diverse biological activities
货号:ajcx21730
CAS:56121-42-7
分子式:C27H28N2O4
分子量:444.5
溶解度:DMSO: soluble,Ethanol: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Asperglaucide is an amide originally isolated fromP. aurantiacumthat has diverse biological activities, including anti-inflammatory, antibacterial, antioxidant, and anticancer properties.1,2,3,4Asperglaucide inhibits production of nitric oxide (NO), prostaglandin E2, and IL-1β in LPS-stimulated BV-2 microglial cells (IC50s = 49.7, 51.5, and 40.4 µM, respectively).2It is active against Gram-negative bacteria (MICs = 0.05-0.10 mg/ml) and has antioxidant activity in 2,2-diphenyl-1-picrylhydrazyl and Trolox equivalent antioxidant capacity (TEAC) assays (EC50s = 9.51-78.81 µg/ml).3Asperglaucide decreases viability of U87 and U251 cancer cellsin vitrowhen used at concentrations ranging from 10 to 100 µM and reduces tumor growth when administered at a dose of 1 mgviaintratumoral injection in a U87 mouse xenograft model.4


1.Banerji, A., and Ray, R.Aurantiamides: A new class of modified dipeptides from Piper aurantiacumPhytochemistry20(9)2217-2220(1981) 2.Yoon, C.S., Kim, D.C., Lee, D.S., et al.Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: Inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cellsInt. Immunopharmacol.23(2)568-574(2014) 3.Tamokou, J.D., Simo Mpetga, D.J., Keilah Lunga, P., et al.Antioxidant and antimicrobial activities of ethyl acetate extract, fractions and compounds from stem bark of Albizia adianthifolia (Mimosoideae)BMC Complement. Altern. Med.1299(2012) 4.Yang, Y., Zhang, L.H., Yang, B.X., et al.Aurantiamide acetate suppresses the growth of malignant gliomas in vitro and in vivo by inhibiting autophagic fluxJ. Cell. Mol. Med.19(5)1055-1064(2015)