PU-H71 hydrate (also known as NSC 750424) is a novel, highly potent and selective inhibitor of HSP90 with IC50 of 51 nM. PU-H71 showed anti-tumor effects in TNBC xenografts, including complete response and tumor regression, without toxicity to the host are achieved with this agent. PU-H71 induces efficient and sustained downregulation and inactivation, both in vitro and in vivo, of these proteins.

纯度：≥98%

CAS：1202865-65-3