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5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine图片
规格:98%
分子量:445.5
包装与价格:
包装价格(元)
250ug电议
500ug电议
1mg电议

产品介绍
An mPGES-1 inhibitor
货号:ajcx21456
CAS:2253745-78-5
分子式:C27H25F2N3O
分子量:445.5
溶解度:Chloroform: 10 mg/ml,Ethanol: 10 mg/ml,Methyl Acetate: 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 66 and 2,730 nM for the human and mouse enzymes, respectively).1It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 µM. It also inhibits LPS-induced prostaglandin E2production in mouse peritoneal cells (IC50= 12 nM).In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.


1.Kal?ic, F., Kolman, V., Ajani, H., et al.Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edemaChemMedChem15(15)1398-1407(2020)