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(±)8(9)-EET-d11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)8(9)-EET-d11图片
规格:98%
分子量:331.5
包装与价格:
包装价格(元)
10ug电议
25ug电议
50ug电议

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx20838
CAS:N/A
分子式:C20H21D11O3
分子量:331.5
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

(±)8(9)-EET-d11contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)8(9)-EET by GC-or LC-mass spectrometry (MS). (±)8(9)-EET is biosynthesized from arachidonic acid in rat and rabbit liver microsomes by CYP450.1,2(±)8(9)-EET is a major P450 metabolite in the renal cortex.3(±)8(9)-EET reduces GFR through cyclooxygenase-dependent preglomerular vasoconstriction.4


1.Chacos, N., Falck, J.R., Wixtrom, C., et al.Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acidBiochem. Biophys. Res. Commun.104(3)916-922(1982) 2.Oliw, E.H., Guengerich, F.P., and Oates, J.A.Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediatesJ. Biol. Chem.257(7)3771-3781(1982) 3.Zhang, J.Y., Prakash, C., Yamashita, K., et al.Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenaseBiochem. Biophys. Res. Commun.183(1)138-143(1992) 4.Katoh, T., Takahashi, K., Capdevila, J., et al.Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidneyAm. J. Physiol.261(4 Pt 2)F578-F586(1991)