您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Cloxacillin-13C4(sodium salt)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Cloxacillin-13C4(sodium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cloxacillin-13C4(sodium salt)图片
包装:1mg
规格:98%
市场价:4074元
分子量:461.8

产品介绍
A neuropeptide with diverse biological activities
货号:ajcx20052
CAS:N/A
分子式:C15[13C4]H17ClN3O5S.Na
分子量:461.8
溶解度:DMSO: slightly soluble,Methanol: slightly soluble,Water: slightly soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Cloxacillin-13C4 is intended for use as an internal standard for the quantification of cloxacillin by GC- or LC-MS. Cloxacillin is a semisynthetic β-lactamase inhibitor.1 It binds to and inactivates penicillin-binding proteins that cross-link peptidoglycans, which are structural components of bacterial cell walls. In vitro, cloxacillin (0.50 μg/ml) completely inhibits B. megaterium growth.2 Cloxacillin inhibits recombinant type Ib penicillinase, P. vulgaris cephalosporinase, and C. freundii cephalosporinase (Kis = 15, 0.27, and 0.027 μM, respectively) as well as S. aureus and S. epidermidis growth (MIC = 0.2 μg/ml for both).3,4 Formulations containing cloxacillin have been used to treat infections caused by methicillin-sensitive staphylococci.1


|1. Bru, J.P., and Garraffo, R. Role of intravenous cloxacillin for inpatient infections. Med. Mal. Infect. 42(6), 241-246 (2012).|2. Wickus, G.G., and Strominger, J.L. Penicillin-sensitive transpeptidation during peptidoglycan biosynthesis in cell-free preparations from Bacillus megaterium. II. Effect of penicillins and cephalosporins on bacterial growth and in vitro transpeptidation. J. Biol. Chem. 247(17), 5307-5311 (1972).|3. Yamaguchi, A., Adachi, A., Hirata, T., et al. Conversion of cloxacillin into a progressive inhibitor of beta-lactamases by sulfonation and its activity against various types of these enzymes. J. Antibiot. (Tokyo) 38(1), 83-93 (1985).|4. Sabath, L.D., Garner, C., Wilcox, C., et al. Susceptibility of Staphylococcus aureus and Staphylococcus epidermidis to 65 antibiotics. Antimicrob. Agents Chemother. 9(6), 962-969 (1976).