HS-10296 是具有口服活性的、表皮生长因子受体 (EGFR) 激活突变体和 T790M 耐药性突变体的第三代抑制剂，对野生型 EGFR 活性有限。
货号:ajcx16860
CAS:1899921-05-1
分子式:C30H35N7O2
分子量：525.64
溶解度:DMSO: ≥ 83.33 mg/mL (158.53 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

HS-10296, an orally available and third-generation EGFR-activating mutations and T790M-resistant mutation inhibitor, shows limited activity against wild-type EGFR[1][2].

[1]. Sullivan I, et al. Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line. Front Med (Lausanne). 2017 Jan 18;3:76. [2]. Wu SG, et al. Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer. Mol Cancer. 2018 Feb 19;17(1):38.